Fig. 2
From: Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma
a shows a scatter plot of the PD-L1 score in each biopsy with tumour proportion score (TPS) and b shows the PD-L1 expression with combined positive score (CPS). In a and b the y-axis depicts the PD-L1 score from 0–100%. The x-axis depicts the 33 lesions ranked by mean PD-L1 score marked with a black circle for TPS and CPS, respectively. The crosses depict the actual score from each of the six biopsies. As an example, in lesion 1 and 2 all biopsies scored 0% in a. The black dashed lines marks 1% cut off and 50% cut-off values. The insert in the upper left corner of both (a) and (b) depicts the negative predictive value of a single negative core biopsy using a 1% cut off and 50% cut off for positivity with TPS (2A) and CPS (2B) in case of one biopsy and with double biopsy. The ground truth is assumed to be that a tumour is positive if any of the six core biopsies are positive. For the five patients with two lesions, lesion 30, 15, 25, 7 and 2 is the primary lesions and lesion 32, 12, 26, 8 and 1 is the corresponding lymph node lesions in a. Lesion 29, 17, 23, 2 and 12 is the primary lesions in b and lesion 32, 15, 24, 5 and 13 the corresponding lymph node lesions
