Fig. 1

Overview of the major lipid metabolism pathways shown to be affected by metabolic stress. The figure highlights all the key lipid metabolism pathways activated in cancer cells. Major pathways are shown as boxes without outlines. The systematic names of these pathways are given at the bottom-right corner of each box. The numbers shown superscripted to each protein/metabolite indicate the reference number. For further details see the text and Supplementary Table 1. ACACA acetyl-CoA carboxylase 1, ACACB acetyl-CoA carboxylase 2, ACSS2 acyl Co-A synthetase-2, ADFP adipose differentiation protein, ATGL adipose triglyceride lipase, FA fatty acids, FABP3 fatty acid binding protein 3, FABP7 fatty acid binding protein 7, FFA free fatty acids, FASN fatty acid synthase, H hypoxia, HIF-1α hypoxia-inducible factor 1-α, HIF-2α hypoxia-inducible factor 2α, HIG2 hypoxia-inducible gene 2 protein, HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase, LD lipid droplet, LCAD long-chain specific acyl-CoA dehydrogenase, MAG monoacylglycerol, MCAD medium-chain acyl-CoA dehydrogenase, MUFA monounsaturated fatty acids, PBMCs peripheral blood mononuclear cells, PC phosphatidylcholines, PE phosphatidylethanolamines, Pcho propargyl-choline, PI phosphatidylinositol, PS phosphatidylserine, PUFA polyunsaturated fatty acids, SCD stearoyl-CoA desaturase, SFA saturated fatty acids, SREBP sterol regulatory element-binding proteins, TG triglycerides