Fig. 5 | British Journal of Cancer

Fig. 5

From: M2 macrophages mediate sorafenib resistance by secreting HGF in a feed-forward manner in hepatocellular carcinoma

Fig. 5

M2 macrophages confer sorafenib resistance by activation of ERK/MAPK and PI3K/AKT pathways through HGF/c-Met signalling. a Treatment with sorafenib, M2-CM, HGF or anti-HGF antibody (aHGF) alone or combination affects the expression and phosphorylation of c-Met, ERK and AKT kinases in SMMC-7721 cells as measured by Western blots. GAPDH is a protein loading control. b Treatment with sorafenib, M2-CM, HGF or anti-HGF antibody (aHGF) alone or combination affects the expression and phosphorylation of c-Met, ERK, and AKT kinases in Hep3B cells as measured by Western blots. GAPDH is a protein loading control

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