Table 1 Association between EMT markers and expression of S100 proteins in PDAC samples

From: ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins

  

S100A2

S100A4

S100A6

S100A14

Vimentin

P-Cad

E-Cad

Slug

Twist

ZEB1

pSTAT3

S100A2

Pearson Correlation

1

0.246

.047

.121

−.001

0.173

0.170

0.030

0.057

0.301

−0.091

Sig. (2-tailed)

 

0.181

0.801

0.517

0.994

0.351

0.362

0.872

0.760

0.100

0.627

N

31

31

31

31

31

31

31

31

31

31

31

S100A4

Pearson Correlation

0.246

1

0.444*

−0.371*

0.042

0.074

−0.409*

0.207

0.310

0.428*

0.470**

Sig. (2-tailed)

0.181

 

0.012

0.040

0.821

0.692

0.022

0.263

0.090

0.016

0.008

N

31

31

31

31

31

31

31

31

31

31

31

S100A6

Pearson Correlation

0.047

0.444*

1

0.096

−0.007

−0.030

0.012

0.156

0.189

0.083

0.387*

Sig. (2-tailed)

0.801

0.012

 

0.607

0.970

0.873

0.948

0.403

0.310

0.657

0.032

N

31

31

31

31

31

31

31

31

31

31

31

S100A14

Pearson Correlation

0.121

−0.371*

0.096

1

−0.589***

0.338

0.828***

−0.088

−0.221

−0.264

−0.261

Sig. (2-tailed)

0.517

0.040

0.607

 

0.000

0.063

0.000

0.636

0.232

0.152

0.155

N

31

31

31

31

31

31

31

31

31

31

31

Vimentin

Pearson Correlation

−0.001

0.042

−0.007

−0.589***

1

−0.180

−0.422*

0.069

0.237

−0.035

0.283

Sig. (2-tailed)

0.994

0.821

0.970

0.000

 

0.332

0.018

0.712

0.199

0.854

0.124

N

31

31

31

31

31

31

31

31

31

31

31

P-Cad.

Pearson Correlation

0.173

0.074

−0.030

0.338

−0.180

1

0.426*

0.210

0.042

0.369*

−0.077

Sig. (2-tailed)

0.351

0.692

0.873

0.063

0.332

 

0.017

0.257

0.823

0.041

0.680

N

31

31

31

31

31

31

31

31

31

31

31

E-Cad.

Pearson Correlation

0.170

−0.409*

0.012

0.828***

−0.422*

0.426*

1

−0.203

−0.318

−0.176

−0.296

Sig. (2-tailed)

0.362

0.022

0.948

0.000

0.018

0.017

 

0.273

0.081

0.345

0.106

N

31

31

31

31

31

31

31

31

31

31

31

Slug

Pearson Correlation

0.030

0.207

0.156

−0.088

0.069

0.210

−0.203

1

0.233

0.310

0.056

Sig. (2-tailed)

0.872

0.263

0.403

0.636

0.712

0.257

0.273

 

0.206

0.090

0.765

N

31

31

31

31

31

31

31

31

31

31

31

Twist

Pearson Correlation

0.057

0.310

0.189

−0.221

0.237

0.042

−0.318

0.233

1

0.125

0.419*

Sig. (2-tailed)

0.760

0.090

0.310

0.232

0.199

0.823

0.081

0.206

 

0.505

0.019

N

31

31

31

31

31

31

31

31

31

31

31

ZEB1

Pearson Correlation

0.301

0.428*

0.083

−0.264

−0.035

0.369*

−0.176

0.310

0.125

1

0.122

Sig. (2-tailed)

0.100

0.016

0.657

0.152

0.854

0.041

0.345

0.090

0.505

 

0.512

N

31

31

31

31

31

31

31

31

31

31

31

p-STAT3

Pearson Correlation

−0.091

0.470**

0.387*

−0.261

0.283

−0.077

−0.296

0.056

0.419*

0.122

1

Sig. (2-tailed)

0.627

0.008

0.032

0.155

0.124

0.680

0.106

0.765

0.019

0.512

 

N

31

31

31

31

31

31

31

31

31

31

31

  1. Asterisks indicate significant positive and negative correlations. *p < 0.05; **p < 0.01; ***p < 0.0001
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