Table 4 Association of body mass index (BMI) and ovarian cancer risk using observed BMI

From: Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

 

N/events

HR (95% CI)

P value

Per 5 kg/m2 increase in BMI at date of questionnaire

  All participants (confounding adjustment sequentially)

    Adjusted for principal components

7516/772

1.00 (0.90–1.10)

0.96

    Additionally adjusted for country

7516/772

0.99 (0.90–1.09)

0.84

    Additionally adjusted for birth cohort

7516/772

1.02 (0.93–1.12)

0.72

    Additionally adjusted for mutation status

7516/772

1.06 (0.96–1.16)

0.26

    Additionally adjusted for menopausal status

7516/772

1.04 (0.95–1.14)

0.42

    Additionally adjusted for parity and age at menarche

6964/715

1.04 (0.94–1.14)

0.48

 By mutation statusa

   BRCA1 carrier

4401/543

1.06 (0.95–1.17)

0.31

  BRCA2 carrier

3115/229

0.96 (0.81–1.15)

0.67

   Pinteraction

  

0.35

 By menopausal statusb

   Premenopausal

7516/102

1.25 (1.06–1.48)

0.009

  Postmenopausal

4257/670

0.98 (0.88–1.10)

0.78

  P interaction

  

0.02

 By tumour subtypec

   Serous

7223/312

0.98 (0.84–1.15)

0.83

   Non-serousd

7223/167

1.25 (1.06–1.49)

0.01

   Phet

  

0.04

 By tumour gradec

   Well or moderately differentiated

7252/109

1.05 (0.84–1.32)

0.65

   Poorly/undifferentiated

7252/268

0.95 (0.82–1.11)

0.54

   Phet

  

0.47

Per 5 kg/m2 increase in BMI in young adulthood

  All participants (confounding adjustment sequentially)

    Unadjusted

5417/536

0.86 (0.69–1.07)

0.17

    Adjusted for country

5417/536

0.86 (0.69–1.08)

0.19

    Additionally adjusted for birth cohort

5417/536

0.87 (0.70–1.08)

0.21

    Additionally adjusted for mutation status

5417/536

0.91 (0.73–1.13)

0.39

    Additionally adjusted for menopausal status

5417/536

0.93 (0.76–1.16)

0.53

    Additionally adjusted for parity and age at menarche

5210/516

0.92 (0.74–1.14)

0.42

 By mutation statusa

   BRCA1 carrier

3134/380

0.92 (0.71–1.18)

0.50

   BRCA2 carrier

2283/156

1.00 (0.74–1.36)

0.99

   Pinteraction

  

0.73

 By menopausal statusb

   Premenopausal

5417/67

1.34 (0.97–1.84)

0.07

  Postmenopausal

3094/469

0.82 (0.65–1.04)

0.11

  P interaction

  

0.01

  1. HR hazard ratio, CI confidence interval
  2. aAdjusted for principal components, birth cohort, country of enrolment, and menopausal status in weighted Cox model
  3. bAdjusted for principal components, mutation status, birth cohort, and country of enrolment
  4. cAdjusted for principal components, birth cohort, country of enrolment, mutation status, and menopausal status
  5. dIncludes endometrioid, mucinous, clear cell, and other histological types
  6. Bolded lines refer to the model corresponding to our main results
Back to article page