Table 6 Height or body mass index (BMI) single-nucleotide polymorphisms (SNPs) statistically significantly associated (P < 0.05) with ovarian cancer risk in CIMBA

From: Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

rs ID

Chromosome

Position

Nearest gene

Reference allele in CIMBA

Effect allele in CIMBA

Effect allele frequency in CIMBA

Imputation qualitya

Association with ovarian cancer in CIMBA

Log hazard ratiob

Standard error

P value

Height

  rs11049611

12

28600244

CCDC91

C

T

0.28

1

0.127

0.036

0.0004

  rs6902771

6

152157881

ESR1

C

T

0.46

0.98

0.091

0.032

0.005

  rs584828

17

38599230

IGFBP4

C

T

0.39

0.68

0.109

0.040

0.006

  rs3817428

15

89415247

ACAN

C

G

0.22

0.51

0.144

0.053

0.006

  rs7517682

1

103519589

COL11A1

G

A

0.56

0.98

0.085

0.033

0.009

  rs12470505

2

219908369

CCDC108

T

G

0.10

0.97

−0.143

0.055

0.009

  rs26024

5

127696022

FBN2

A

C

0.34

1

−0.087

0.034

0.011

  rs13113518

4

56399648

CLOCK

T

C

0.37

0.99

0.081

0.033

0.014

  rs7319045

13

92024574

GPC5

A

G

0.61

0.92

0.084

0.035

0.017

  rs2044124

17

61845425

CCDC47

T

C

0.95

0.91

0.187

0.079

0.018

  rs9309101

2

43629612

THADA

A

G

0.35

1

0.076

0.033

0.021

  rs11867943

17

54229842

ANKFN1

A

T

0.11

0.96

0.118

0.051

0.022

  rs12779328

10

12943973

CCDC3

C

T

0.30

0.94

−0.080

0.036

0.026

  rs8073371

17

46096276

COPZ2

C

T

0.20

1.00

−0.095

0.043

0.029

  rs2013265

8

24092500

ADAM28

C

T

0.22

0.62

0.104

0.047

0.029

  rs11687941

2

242191410

HDLBP

C

G

0.26

0.96

−0.079

0.037

0.031

  rs6838153

4

122720999

EXOSC9

A

G

0.33

0.99

−0.072

0.034

0.033

  rs7112925

11

66826160

RHOD

C

T

0.36

0.95

−0.071

0.034

0.037

  rs16942341

15

89388905

ACAN

C

T

0.03

0.60

0.255

0.123

0.039

  rs6080830

20

17771113

BANF2

A

G

0.43

0.68

−0.080

0.039

0.041

  rs867245

4

2218888

POLN

C

G

0.07

1.00

0.122

0.060

0.043

  rs1155939

6

126866133

C6orf173

C

A

0.51

0.99

0.064

0.033

0.049

BMI

  rs16851483

3

141275436

RASA2

G

T

0.07

1

−0.203

0.068

0.003

  rs2207139

6

50845490

TFAP2B

A

G

0.16

0.99

0.120

0.043

0.005

  rs2033732

8

85079709

RALYL

T

C

0.75

0.72

−0.088

0.042

0.037

  rs6804842

3

25106437

RARB

A

G

0.58

0.58

0.087

0.044

0.046

  1. CIMBA Consortium of Investigators for the Modifiers of BRCA1/2
  2. aImputation quality of 1 indicates genotyped SNPs
  3. bPer-allele association with ovarian cancer was adjusted for principal components, birth cohort, menopausal status, age at menopause, country of enrolment, and mutation status in weighted Cox models
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