Fig. 2
Distribution of CLDN18-positive primary cases: among gastro-oesophageal (GEC) and gastric (GC) carcinomas (a), according to location within the gastric mucosa (b), according to tumour histotypes (c) and according to tumour grading (d). e CLDN18 status assessed in matched primary and metastatic tumours (n = 128). f Graphic summary of clinicopathological and immunohistochemical/in situ hybridisation results observed in the present study. Cases are disposed in columns, clinicopathological and molecular features in rows; missing data are in black, positive data are in red (i.e. high-CLDN18 expression; HER2 overexpression or amplification; presence of alterations in the proteins of the DNA mismatch repair; EBER-positive staining; p53 aberrant cases; E-cadherin-negative cases; p16-negative cases). Lauren lighter lines: diffuse-type carcinomas; Ming lighter lines are cases with expansive growth pattern; tumour staging from yellow (stage I) to dark red (stage IV); tumour grading from light blue (grade 1) to dark blue (grade 3)
