Table 3 Pooled Positive Predictive Value (PPV) of DNA methylation assays for detection of CIN2+ and CIN3+
CIN2+ detection | Model 1a | Model 2b | ||||||
|---|---|---|---|---|---|---|---|---|
Observed prevalence | PPV (95% CI) | Set prevalence | ||||||
5% | 10% | 20% | 30% | 40% | 50% | |||
PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | |||
All studies (n = 38)10,24,25,26,27,28,29,30,31,33,34,35,36,37,38,39,40,42,43,45,46,47,48,49,52,53,54,55,56,57,58,59,60,61,62,63,65 | 36.7% | 57.6 (50.3–64.6) | 12.1 (10.2–14.0) | 22.6 (19.4–25.7) | 39.6 (35.3–43.9) | 52.9 (48.4–57.4) | 63.6 (59.4.3–67.8) | 72.4 (68.8–76.0) |
p-heterogeneity | 25.1 (17.1–35.2) | |||||||
Threshold to achieve 70% specificity (n = 24 studies)10,24,25,26,27,28,29,31,33,35,37,39,42,46,48,55,56,56,58,59,60,63,65 | 35.7% | 53.4 (44.4–62.1) | 7.2 (4.5–9.8) | 14.0 (9.2–18.8) | 26.8 (19.0–34.7) | 38.6 (29.1–48.1) | 49.5 (39.4–59.5) | 59.5 (49.8–69.1) |
p-heterogeneity | 27.5 (17.1–41.0) | |||||||
Threshold to achieve 50% specificity (n = 17 studies) specificity10,25,27,28,33,34,35,37,39,42,48,49,55,57,58,60 | 34.9% | 43.8 (35.2–2.7) | 7.7 (7.3–8.1) | 15.0 (14.2–15.7) | 28.4 (27.2–29.6) | 40.4 (39.0–41.8) | 51.4 (49.9–52.8) | 61.3 (59.9–62.7) |
p-heterogeneity | 25.5 (13.8–42.1) | |||||||
CIN3+ detection | Model 1a | Model 2b | ||||||
|---|---|---|---|---|---|---|---|---|
Observed prevalence | PPV (95% CI) | Estimated prevalence | ||||||
5% | 10% | 20% | 30% | 40% | 50% | |||
PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | PPV (95% CI) | |||
All studies (n = 30)10,25,26,27,27,29,30,31,32,34,35,38,40,41,42,44,46,47,48,49,50,51,52,53,54,56,58,62,63,65 | 21.6% | 40.8 (33.9–48.0) | 12.7 (11.0–14.5) | 23.6 (20.8–26.3) | 41.0 (37.2–44.7) | 54.3 (50.5–58.1) | 64.9 (61.4–68.4) | 73.5 (70.5– 76.5) |
p-heterogeneity | 17.0 (10.2–27.9) | |||||||
Threshold to achieve 70% specificity (n = 19 studies)10,25,26,27,27,29,31,32,35,41,42,44,46,48,51,53,58,63,65 | 19.8% | 35.0 (28.9–41.6) | 11.0 (10.2–11.8) | 20.7 (19.4–22.1) | 37.0 (35.2–38.9) | 50.2 (48.2–52.2) | 61.1 (59.1–63.0) | 70.2 (68.5–71.9) |
p-heterogeneity | 12.6 (6.0–24.3) | |||||||
Threshold to achieve 50% specificity (n = 14)10,25,27,32,34,35,42,44,48,49,51,58,65 | 19.0% | 26.5 (21.3–32.4) | 8.0 (7.5–8.4) | 15.5 (14.7–16.3) | 29.2 (27.9–30.4) | 41.4 (39.9–42.6) | 52.3 (50.8–53.8) | 62.2 (60.8–63.6) |
p-heterogeneity | 14.1 (5.8–30.4) | |||||||
