Fig. 6 | British Journal of Cancer

Fig. 6

From: Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages

Fig. 6

Celecoxib synergises gemcitabine during PDAC treatment. a PANC-1 and BxPC-3 cells were treated with vehicle, celecoxib, gemcitabine, or gemcitabine plus celecoxib. The levels of pmTOR, mTOR, pAKT, AKT, pNF-κB, NF-κB, caspase-3 and cleaved caspase-3 were determined using western blotting. b–d Orthotopic pancreatic cancer mice were treated as indicated for two weeks. b Tumours are shown. c Tumour weights were analysed (n = 5). d The expression of the indicated proteins was analysed using immunohistochemical staining. Scale bar represents 25 µm. Data are presented as the mean ± SD. *P < 0.05, ***P < 0.001, ns, no significance

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