Table 3 1-year survival probability comparison between cancer morphology (NENs vs non-NENs) and association between stage at diagnosis (localised vs metastasized) and cancer morphology for people diagnosed in England 2013–2015

From: Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013–2015

Site

Total number of cases (stage I–IV) (n)

1-year overall survival probability (%)

Association between NEN morphology and a diagnosis at stage 4

NENs

Non-NENs

NENs (95% CI)

Non-NENs (95% CI)

OR (95% CI) (unadjusted)

p-value

OR (95% CI) (age-and sex-adjusted)

p-value

Bladder

362

19,859

52.4 (47.4–57.1)

74.9 (74.4–75.5)

3.2 (2.6–4.0)

<0.000

3.2 (2.6–4.1)

<0.000

Breast

51

117,052

82 (68.3–90.2)

96.5 (96.4–96.6)

3.9 (1.9–8.2)

<0.000

3.7 (1.8–7.7)

<0.000

Colon and caecum

458

50,850

67.4 (62.8–71.6)

82.6 (82.3–82.9)

4 (3.3–4.8)

<0.000

3.8 (3.2–4.6)

<0.000

Female reproductive organs

202

40,376

64.7 (57.4–71.1)

89.5 (89.2–89.8)

4.2 (3.2–5.7)

<0.000

5.2 (3.9–7)

<0.000

Oesophagus

296

16,383

35.3 (29.6–41)

51.6 (50.8–52.4)

3.3 (2.6–4.2)

<0.000

3.6 (2.8–4.5)

<0.000

Pancreas

838

8,936

77.6 (74.5–80.3)

31 (29.7–31.5)

0.6 (0.5–0.7)

<0.000

0.5 (0.5–0.7)

<0.000

Prostate

52

98,963

21.1 (11.3–33.0)

95.5 (95.4–95.6)

41.7 (16.6–104.9)

<0.000

45.1 (17.8–113.9)

<0.000

Pulmonary

1965

72,672

74.9 (72.9–76.8)

47.2 (46.8–47.6)

0.4 (0.4–0.5)

<0.000

0.4 (0.4–0.5)

<0.000

Rectum

333

23,498

76.4 (71.4–80.7)

86.8 (86.4–87.3)

1.6 (1.3–2)

<0.000

1.5 (1.2–2.0)

<0.000

Skin (non-melanoma)a

876

81,671

74.4 (71.6–77)

92 (91.8–92.2)

ND

ND

ND

ND

Small Intestine

1164

1157

91.2 (89.4–92.7)

61 (58.4–63.1)

0.9 (0.8–1.1)

0.314

0.9 (0.8–1.1)

0.326

Stomach

278

10,938

63.4 (57.3–68.9)

48 (47.4–49.1)

1.0 (0.8–1.3)

0.24

0.9 (0.8–1.2)

0.881

  1. Excluding morphologies neoplasm NOS, carcinoma NOS, tumour cells NOS and basal cell carcinomas
  2. ND not determined
  3. anon-melanoma skin cancers not staged