Fig. 4 | British Journal of Cancer

Fig. 4

From: EWS-FLI1-mediated tenascin-C expression promotes tumour progression by targeting MALAT1 through integrin α5β1-mediated YAP activation in Ewing sarcoma

Fig. 4

MALAT1 upregulation induced by TNC. a, b Differential gene expression is delineated in a heat map (normalised counts >10, ∣log2 fold change ∣> 1.5) and volcano plot (n = 3 replicates per group, A673 cells). c Enriched KEGG pathways were determined by using clusterProfiler R package version 3.4.1. d, e,Representative images and statistical analysis of MALAT1 expression in ES clinical specimens (scale bars, 100 μm). f Relative MALAT1 relative mRNA expression compared with the wild-type group was upregulated by transfection with Flag-TNC plasmid (p < 0.01 in A673 cells, p < 0.001 in SKNMC cells), and downregulated dramatically by TNC depletion (p < 0.001) (normalised to GAPDH expression)

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