Table 2 Univariate Cox Regression analysis of overall survival for patients stratified by median cell expressiona

From: Spatial proximity between T and PD-L1 expressing cells as a prognostic biomarker for oropharyngeal squamous cell carcinoma

 

HPV positive

 

HPV negative

 

All

 

Cell population

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

T cells

CD8+

0.56 (0.21, 1.50)

0.25

1.03 (0.47, 2.26)

0.94

0.84 (0.46, 1.54)

0.57

CD8+PD-1+

0.76 (0.29, 1.99)

0.57

1.88 (0.85, 4.16)

0.12

1.16 (0.63, 2.14)

0.63

Macrophages

CD68+

1.34 (0.51, 3.53)

0.55

0.34 (0.14, 0.79)

0.01

0.58 (0.32, 1.07)

0.08

CD68+PD-L1+

1.33 (0.51, 3.45)

0.56

1.50 (0.67, 3.34)

0.32

1.34 (0.73, 2.47)

0.34

PD-L1 and PD-1

PD-L1+

1.36 (0.52, 3.52)

0.53

1.50 (0.67, 3.34)

0.32

1.42 (0.77, 2.60)

0.26

PD-1+

0.60 (0.22, 1.60)

0.31

1.84 (0.83, 4.07)

0.14

1.06 (0.57, 1.94)

0.86

  1. aVariables stratified by the median to distinguish patients with high and low expression. Percentage cell expression was first assessed for individual ROIs, and the median expression from all ROI was selected to represent the patient
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