Fig. 4 | British Journal of Cancer

Fig. 4

From: High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer

Fig. 4The alternative text for this image may have been generated using AI.

Molecular pathways associated with PI-PUFA accumulation in invasive cancers. a Gene ontology of the pathways differentially activated in the tumours with or without PI(18:0/20:3) accumulation. b The pathways related to the immune response that are differentially activated in invasive breast tumours with or without PI(18:0/20:3) accumulation. “–Log (p-value)” of each pathway is shown. c A heatmap illustrating the expression of individual genes related to “inhibitory PD-1 signalling in T cells” (upper) and “unsaturated fatty acid trafficking and synthesis” (lower). Gene expression values are indicated by a blue to yellow colour scale (top bar). The presence or absence of PI(18:0/20:3) accumulation in histological images is shown in purple and yellow, respectively. The values of the PM ratio are indicated by a rainbow colour scale (bottom bar). Tumour subtypes are shown in red (luminal), blue (triple negative), orange (luminal Her2), yellow (Her2) and grey (pure DCIS).

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