Table 3 Clinical characteristics of the five ovarian cancer patients with stable disease for over 200 days.

From: Results of a phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumours

 

Baseline characteristics

6MP study treatment details

Patient ID

Mutated BRCA gene

Prior PARP treatment

Volume of disease

TPMT status

6MP starting dose (mg)

Mean daily 6MP dose intensity (mg)

No. of days on trial

Patient 1

1

Yes

Visceral

High/high

140

98.1

303

Patient 2

1

No

Visceral

High/high

130

93.2

287

Patient 3

2

Yes

Visceral

High/high

120

58.7

260

Patient 4

1

Yes

Nodal only

High/high

110

98.3

455

Patient 5

2

No

Visceral

High/high

100

67.6

252*

  1. *Still on treatment at the time of analysis.