Fig. 5: Combinational TCP and GSK-J1 treatment induces hundreds of differentially expressed genes enriched in cancer-associated biological events and pathways. | British Journal of Cancer

Fig. 5: Combinational TCP and GSK-J1 treatment induces hundreds of differentially expressed genes enriched in cancer-associated biological events and pathways.

From: Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1

Fig. 5

a The heatmaps showing the differentially expressed genes by genome-wide transcriptional sequencing after TCP and GSK-J1 treatment in Cal27 cells. n = 2 biological replicates for each condition. b, c Gene ontology (b) and KEGG pathway (c) analyses of those differentially expressed genes revealed significant enrichment in cancer-related biological categories and pathways. d–g Gene set enrichment analysis (GSEA) of those differentially expressed genes revealed significant enrichment in apoptosis, cell cycle, cyclin D1 and p53 pathway.

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