Table 1 Patient demographics and baseline characteristics.

From: A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours

 

Total (N = 22)

Age (years)

  Mean (SD)

58.8 (9.7)

  Range

38.0–78.0

Sex (n; %)

  Female

13 (59.1)

  Male

9 (40.9)

ECOG PS (n; %)

  0—Fully active

14 (63.6)

  1—Restricted in physically strenuous activity

8 (36.4)

Tumour type (n; %)

  Colorectal

5 (22.7)

  Breast

3 (13.6)

  Sarcoma (of the thigh, uterus and stomach)

3 (13.6)

  Uterus

2 (9.1)

  Pancreas

2 (9.1)

  Liver

1 (4.5)

  Oesophagus

1 (4.5)

  Ovary

1 (4.5)

  Small intestine

1 (4.5)

  Stomach

1 (4.5)

  Testicles

1 (4.5)

  Vater ampulla

1 (4.5)

Number of metastatic sites

  Median (range)

2 (0–5)

Prior lines of anticancer therapy (n; %)

  1

1 (4.5)

  2

2 (9.1)

  ≥3

19 (86.4)