Fig. 4: PRC2 is recruited to the hepaCAM promoter region to trigger methylation. | British Journal of Cancer

Fig. 4: PRC2 is recruited to the hepaCAM promoter region to trigger methylation.

From: Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM

Fig. 4: PRC2 is recruited to the hepaCAM promoter region to trigger methylation.

a The human hepaCAM locus is shown by the UCSC Genome Browser. b TCGA database analysed the differential mRNA expression of hepaCAM, EZH2, SUZ12 and EED in PCa at various stages and normal tissues; ***P < 0.001. c–f ChIP-PCR suggested that HOTAIR-regulated PRC2 inhibited the expression of hepaCAM via H3K27me3. Data are shown as the mean ± SD (n = 3), NS, not significant, *P < 0.05, **P < 0.01, ***P < 0.001. g HOTAIR recruited PRC2 to a specific hepaCAM promoter region.

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