Fig. 3: Associations between DMR methylation and patient prognosis. | British Journal of Cancer

Fig. 3: Associations between DMR methylation and patient prognosis.

From: Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia

Fig. 3: Associations between DMR methylation and patient prognosis.

a–c Kaplan–Meier plots for post-treatment survival in patients within the ICGC cohort (n = 139) stratified by methylation level (high/low) of HOXA4 (a), SLCO3A1 (b) and MAFB (c). d–g Pyrosequencing-based analysis of HOXA4 methylation within the Newcastle cohort (n = 163). Kaplan–Meier plots for post-treatment survival (d) and overall survival (e) by HOXA4 methylation (high/low). HOXA4 methylation by Binet stage (f), with lines indicating median values, boxes the interquartile range (IQR), whiskers the highest and lowest values within 1.5*IQR and outliers displayed as individual points. HOXA4 methylation at sequential timepoints among 18 untreated patients (g), with lines indicating samples from the same patient.

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