Fig. 4: Genomic events positively and negatively associated with MIRACLE.

Top 40 of the mutated genes with negative non-zero coefficients of a trained elastic net model. One hundred and eighty-six identified genes whose mutation is associated with a decrease of the MIRACLE (left panel). Top 40 mutated genes with a positive association with MIRACLE score in pan-cancer trained model (right panel). Contributions of each individual cancer type to the coefficient in trained elastic net model are proportionally indicated by the size of the bars.