Fig. 4: Tumorigenicity of CD63–BCAR4 fusion.
From: A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis
a Tumour formation over 19 weeks in NOG mice transplanted with vector, CD63–BCAR4 or BCAR4-overexpressing BEAS-2B cells. Tumour growth was monitored after the subcutaneous injection of stable cell lines to NOG mice. The results are shown as the means ± SD (n = 8/group). Statistical significances are marked with **(p < 0.005). The representative image of the xenografted mice is demonstrated. GFP protein was used as a transduction marker of lentiviral vector. b Resected tumour specimens and liver from the subcutaneously transplanted mice. c H&E-stained tissues from metastatic tumours in the liver (front, back) and lung (front, back) of the xenograft mice injected with CD63–BCAR4-overexpressing cells.
