Fig. 5: NCB-0846 inhibits metastatic potential. | British Journal of Cancer

Fig. 5: NCB-0846 inhibits metastatic potential.

From: Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846

Fig. 5

a Representative images of lungs (from top to bottom: unfixed, formalin-fixed, and HE-stained tissue sections) resected from mice 7 weeks after injection of A549 cells treated with TGF-β1 (5 ng/mL) and DMSO, TGF-β1 and NCB-0846 (3 µM) or TGF-β1 and NCB-0970 (3 µM) for 48 h. Scale bar represents 5 mm. b Summed areas of metastases relative to the total lung areas of mice injected with A549 cells treated as described in the legend to Fig. 5a. Error bars represent SD. ***P < 0.001. c Wet lung weights of mice injected with A549 cells treated as described in the legend to Fig. 5a. Error bars represent SD. ***P < 0.001; **P < 0.01.

Back to article page