Fig. 1: BMBC history.
From: Treatment strategies for breast cancer brain metastases
Following haematogenous dissemination, breast cancer cells invade the brain tissue by extravasation. Then they experience perivascular growth with no need of neoangiogenesis and the blood–brain barrier (BBB) is still intact. To reach macroscopic size, the new metastasis needs to stimulate neoangiogenesis. At this point, the BBB may be disrupted and is referred as the blood–tumour barrier (BTB). This Figure has been adapted from Eicher et al.29.
