Fig. 1: Schematic overview of the EMTome.
From: EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures
a The transformation between epithelial and mesenchymal cells during cancer metastasis is orchestrated through multiple genomic changes that eventually lead to primary site escape, intravasation and formation of a tumour at a secondary site. b Schematic of the EMTome database. The EMT core signature module allows the user to explore EMT signatures and the markers associated with each signature across cancer types. The EMT-related gene retrieval module can be used to explore EMT-related genes for changes at the transcriptomic, epigenomic or proteomic level. The EMT-related gene interactome module can be used to search for significant associations between gene RNA expression and the transcriptomic landscape, copy number events, methylation, miRNA and proteins (RPPA). The fourth module is the EMT-signature score module. c The EMT-signature score module facilitates calculation of correlations between the normalised EMT score and RNA expression, survival comparisons across cancer types, and evaluation of genetic dependency of EMT-related genes and available drug sensitivity information.
