Table 1 Patient characteristics according to NLR (<5 or ≥5) in this study (n = 63).

From: Prognostic impact of peripheral blood neutrophil to lymphocyte ratio in advanced-stage pulmonary large cell neuroendocrine carcinoma and its association with the immune-related tumour microenvironment

 

All patients

NLR < 5

n = 47

NLR ≥ 5

n = 16

p

Age, median (range), in years

62 (28–79)

63 (28–79)

62 (48–79)

 

Age, n (%)

 <75 years

56 (88.9)

42 (89.4)

14 (87.5)

 

 ≥75 years

7 (11.1)

5 (10.6)

2 (12.5)

1.00*

Gender, n (%)

 Male

55 (87.3)

41 (87.2)

14 (87.5)

 

 Female

8 (12.7)

6 (12.8)

2 (12.5)

1.00*

Smoking status, n (%)

 Never

4 (6.3)

3 (6.4)

1 (6.2)

 

 Former/current

59 (93.7)

44 (93.6)

15 (93.8)

1.00*

ECOG PS, n (%)

 0–1

60 (95.2)

46 (97.8)

14 (87.5)

 

 2/3–4

3 (4.8)/0 (0)

1 (2.2)/0 (0.0)

2 (12.5)/0 (0.0)

0.16*

Stage, n (%)

 IIIB

6 (9.5)

5 (10.6)

1 (6.2)

 

 IV

30 (47.6)

21 (44.7)

9 (56.3)

 

 Recurrence

27 (42.9)

21 (44.7)

6 (37.5)

0.77*

Brain metastasis, n (%)

 Yes

14 (22.2)

8 (17.1)

6 (37.5)

 

 No

49 (77.8)

39 (82.9)

10 (62.5)

0.16*

Blood tests, average ± SD

 Alb, g/dL

3.9 ± 0.5

4.0 ± 0.4

3.5 ± 0.6

0.01**

 LDH, IU/L

473 ± 707

389 ± 400

719 ± 1219

0.31**

 CRP, mg/dL

1.7 ± 3.4

0.8 ± 1.5

4.4 ± 5.6

0.02**

 NSE, ng/mL

47.3 ± 67.0

46.4 ± 74.1

46.9 ± 40.7

0.86**

 Pro-GRP, pg/mL

704 ± 3757

893 ± 4350

158 ± 444

0.50**

  1. NLR neutrophil-to-lymphocyte ratio, ECOG Eastern Cooperative Oncology Group, Alb albumen, LDH lactate dehydrogenase, CRP C-reactive protein, NSE neuron-specific enolase, pro-GRP pro-gastrin-releasing peptide
  2. *p values were analysed using the χ² test.
  3. **p values were analysed using the t-test.