Fig. 2: IC50 value fingerprint profiling of HER2 TKIs.
From: Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors
Comparison of the cellular inhibition profile of 12 kinase inhibitors, including EGFR and HER2 inhibitors. Neratinib (blue), Lapatinib (orange), and Tucatinib (green) were tested on 115 cancer cell lines. The other inhibitors were profiled on 102 cancer cell lines. 10logIC50 profiles were compared by Pearson correlation. Compounds (circles) were connected when the Pearson correlation was >0.5.
