Table 2 Reported cases of lactic acidosis in patients with solid malignancies.
Malignancy | Age | Lactate range (mmol/L) | Arterial pH | Liver metastases present | Intervention | Outcome | Ref. |
|---|---|---|---|---|---|---|---|
Breast adenocarcinoma | 86 | 7.5–12 | 7.35 | Yes | Thiamine Sodium bicarbonate Chemotherapy | Died (weeks) | |
Breast adenocarcinoma | 31 | 16 | NS | Yes | Thiamine Sodium bicarbonate Supportive care | Died (8 h) | |
Colorectal adenocarcinoma | 64 | 7.2–20.1 | 6.99 | Yes | Sodium bicarbonate Multivitamins Supportive care | Died (6 days) | |
Colorectal adenocarcinoma | 44 | >11 | 7.24 | Yes | Sodium bicarbonate Chemotherapy Starch loading Thiamine Hydrochlor-thiazide | Resolved | |
Prostate adenocarcinoma | 81 | 9.5–13.6 | 7.23 | Yes | Chemotherapy Prednisolone Thiamine Sodium bicarbonate | Died (days) | |
Gastric adenocarcinoma | 81 | 4.0–6.6 | 7.43 | Yes | Supportive care | Died (days) | |
Squamous cell lung cancer | 84 | 13.5–14 | 7.13 | No | Sodium bicarbonate | Died (15 days) | |
SCLC | 55 | 26 | 7.17 | Yes | Radiotherapy Chemotherapy | Died (5 days) | |
SCLC | 57 | 25.5 | 7.18 | Yes | NS | Died | |
SCLC | 79 | 4.5 | 7.33 | Yes | NS | NS | |
SCLC | 70 | 15 | 7.29 | No | Chemotherapy Sodium bicarbonate | Resolved | |
SCLC | 73 | 4.9–25 | 6.8 | Yes | Sodium bicarbonate Supportive care | Died (days) | |
Small-cell carcinoma of the liver | 77 | 13 | 7.14 | Primary in the liver | Supportive care | Died (days) | |
CUP | 25 | 171.5 | 7.08 | Yes | Haemodialysis Sodium bicarbonate | Died (8 days) | |
CUP | 76 | 7.7 | NS | Yes | Sodium bicarbonate CRRT | Died (15 days) | |
CUP | 14 | NS | NS | Yes | Chemotherapy Supportive care | Died (2 months) | |
Melanoma | 49 | 6.8–16 | 7.05 | Yes | Haemofiltration Sodium bicarbonate Multivitamins Supportive care | Died (2 months) |
