Fig. 5: LA decreases the expression of Ki67 and IGF-1R.
From: Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
IHC was conducted on nine breast tumours. Paraffin sections were stained with standard haematoxylin–eosin–safran stains. a Ki67 labelling was performed 48 h after LA (2 mM) or 2% ethanol treatment in addition to the non-treated tumours. Nuclear localisation was noted (thick black arrows). Harris’ haematoxylin counterstain. b Scatterplot showing the Ki67 staining mean score in LA-treated tumours compared with non-treated (NT) tumours; unpaired two-tailed Student’s t test was used for statistical analysis with P value < 0.05. c IGF-1R labelling was done 48 h after LA (2 mM) or 2% ethanol treatment in addition to the NT tumours.
