Table 3 DOR, sensitivity, specificity and likelihood ratios with calculated 95% confidence intervals for each study in patients sub-grouped by INSS stage.

From: Diagnostic accuracy of circulating-free DNA for the determination of MYCN amplification status in advanced-stage neuroblastoma: a systematic review and meta-analysis

Study

DOR (95% CI)

Sens (95% CI)

Spec (95% CI)

PLR (95% CI)

NLR (95% CI)

INSS stage 3

  Combaret et al.13

51.0 (1.70–1525.8)

0.80 (0.38–0.96)

1.00 (0.68–1.00)

13.5 (0.9–207.6)

0.265 (0.066–1.068)

  Gotoh et al.14

75.0 (1.16–4868.6)

1.00 (0.34–1.00)

1.00 (0.65–1.00)

13.3 (0.9–204.7)

0.178 (0.014–2.247)

  Combaret et al.12

91.0 (3.05–2718.1)

0.75 (0.30–0.95)

1.00 (0.83–1.00)

28.0 (1.7–458.8)

0.308 (0.081–1.176)

  Combaret et al.15

152.8 (7.60–3060.2)

0.75 (0.51–0.90)

1.00 (0.88–1.00)

41.2 (2.6–651.7)

0.270 (0.122–0.596)

  Kojima et al.16

75.0 (1.16–4868.6)

1.00 (0.34–1.00)

1.00 (0.65–1.00)

13.3 (0.9–204.7)

0.178 (0.014–2.247)

  Yagyu et al.17

66.0 (5.20–833.6)

0.92 (0.65–0.99)

0.86 (0.60–0.96)

6.4 (1.8–23.4)

0.097 (0.015–0.643)

  Ma et al.18

81.0 (1.14–5778.7)

1.00 (0.21–1.00)

1.00 (0.77–1.00)

21.0 (1.2–358.4)

0.259 (0.023–2.865)

INSS stage 4

  Combaret et al.13

1105.0 (43.2–28280.7)

1.00 (0.87–1.00)

0.97 (0.85–0.99)

22.2 (4.6–106.4)

0.020 (0.001–0.313)

  Gotoh et al.14

999.0 (18.63–53582.1)

1.00 (0.77–1.00)

1.00 (0.82–1.00)

36.6 (2.4–565.8)

0.037 (0.002–0.558)

  Combaret et al.12

85.0 (6.81–1061.0)

0.91 (0.62–0.98)

0.89 (0.69–0.97)

8.6 (2.3–32.5)

0.102 (0.016–0.663)

  Combaret et al.15

912.08 (50.0–16628.0)

0.85 (0.72–0.93)

1.00 (0.96–1.00)

142.0 (8.9–2258.4)

0.156 (0.077–0.316)

  Kojima et al.16

377.0 (6.7–21160.0)

1.00 (0.78–1.00)

1.00 (0.61–1.00)

13.5 (0.9–195.9)

0.036 (0.002–0.552)

  Yagyu et al.17

211.2 (23.4–1908.8)

0.87 (0.73–0.94)

0.97 (0.85–0.99)

28.7 (4.1–198.2)

0.136 (0.060–0.308)

  Ma et al.18

188.0 (15.2–2324.4)

0.89 (0.57–0.98)

0.96 (0.86–0.99)

21.8 (5.5–86.3)

0.116 (0.018–0.736)

  1. DOR diagnostic odds ratio, NLR negative likelihood ratio, PLR positive likelihood ratio, Sens sensitivity, Spec specificity.