Table 4 Summary of the diagnostic accuracy of MNA assessment in cfDNA of patients with INSS stage 3 and/or 4 NB with calculated 95% confidence intervals.

From: Diagnostic accuracy of circulating-free DNA for the determination of MYCN amplification status in advanced-stage neuroblastoma: a systematic review and meta-analysis

INSS stage

Sens (95% CI)

Spec (95% CI)

PLR (95% CI)

NLR (95% CI)

DOR (95% CI)

3 and 4

0.908 (0.818–0.956)

0.976 (0.940–0.991)

38.6 (1.8–75.5)

0.094 (0.027–0.161)

410.0 (−103.6–923.7)

3

0.832 (0.677–0.921)

0.999 (0.109–1.000)

1321.2 (−11172.2–13814.6)

0.168 (0.048–0.288)

7855.2 (−66267.0–81977.4)

4

0.930 (0.838–0.972)

0.974 (0.937–0.990)

36.4 (3.6–69.3)

0.072 (0.009–0.134)

508.7 (−85.8–1103.2)

  1. DOR diagnostic odds ratio, NLR negative likelihood ratio, PLR positive likelihood ratio, Sens sensitivity, Spec specificity.
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