Fig. 3: Comparison of gene expression profiles of CTC fractions using the five melanoma-specific RT-PCR and the 19 genes ddPCR.
From: Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells
Number of CTCs detected by a multimarker immunostaining protocol of their respective matching sample is indicated to the right and positive CTC counts are shown in red on the far right of figure. The genes with positive detection by RT-PCR (a, orange) or ddPCR (b, red) are shown for each CTC fraction, and the colour of each box represents the expression level for a particular gene and CTC fraction (log scale—indicated below). CTC scores from the ddPCR b are also indicated. Colour boxes indicate samples positive for genes categorised either as a melanocyte lineage (green), cancer-related (blue) or cancer testis antigen (pink). NA data not available.
