Fig. 2: Selective targeting of XCL1-OT-I to XCR1+ DCs. | British Journal of Cancer

Fig. 2: Selective targeting of XCL1-OT-I to XCR1+ DCs.

From: Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade

Fig. 2: Selective targeting of XCL1-OT-I to XCR1+ DCs.The alternative text for this image may have been generated using AI.

a–d Flt3L-induced BM DCs from control (Xcr1+/venus, filled circles) or XCR1-deficient (Xcr1venus/venus, open circles) mice were incubated with indicated concentrations of XCL1-OT-I (a, b) or OVA protein (c, d) for 6 h, and analysed by a flow cytometer. Percentages of CD11c+CD24highCD11bint cells (cDC1) (a, c) and CD11c+CD24intCD11bhigh cells (cDC2) (b, d) expressing OT-I/H-2Kb complex are shown. Similar data were obtained from two independent experiments. *p < 0.05.

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