Table 2 Combination indices (CI) for U251, ULM-GBM-PC38, ULM-GBM-PC40 and ULM-GBM-PC128 glioblastoma cells treated with the indicated concentrations of ONC201/TIC10 and 2-Deoxyglucose.

From: Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma

ONC201/TIC10 [µM]

2-Deoxyglucose [mM]

U251

ULM-GBM-PC38

ULM-GBM-PC40

ULM-GBM-PC128

CI

CI

CI

CI

50.0

10.0

0.47373

1.04881

0.33512

1.40290

50.0

0.625

0.05934

0.21674

0.08282

0.32259

25.0

5.0

0.50843

0.67757

0.31775

0.84413

25.0

0.125

0.01275

0.29085

0.17130

0.46780

12.5

2.5

0.21513

0.39476

0.24273

0.73843

6.25

5.0

0.41143

0.76281

0.55511

0.90978

6.25

1.25

0.29965

0.25774

0.17162

0.52630

3.125

10.0

0.74977

1.35216

0.63504

1.40078

3.125

0.625

0.11225

0.44404

0.14308

0.45498

  1. A CI < 1 indicates synergism, a CI = 1 indicates additive action and a CI > 1 indicates antagonism.
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