Fig. 4: Mutational signature processes in HGSOC metastasis. | British Journal of Cancer

Fig. 4: Mutational signature processes in HGSOC metastasis.

From: Genetic heterogeneity and evolutionary history of high-grade ovarian carcinoma and matched distant metastases

Fig. 4

a The percentage mutational contribution, in primary HGSOC and metastasis, to the 30 published mutational signatures from the COSMIC database. Increasing intensity represents increasing contribution of mutations. b The overall mutational contribution from the cohort to the 30 mutational signatures at primary and metastasis. Integers for significantly correlated signatures have been presented. ‘P’ represents primary tumour, ‘CO’ contralateral ovarian metastatic tumour and ‘M’ metastatic tumour.

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