Table 1 Patient and disease characteristics at baseline.

From: Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

 

Patients (n = 41)

Sex, n (%)

  Female

22 (54%)

  Male

19 (46%)

Age, median (range), years

62 (43–81)

Tumour types, n (%)

  Colorectal

27 (66%)

  Non-small-cell lung cancer

11 (27%)

  Pancreatic

3 (7%)

ECOG PS, n (%)

  0

16 (39%)

  1

25 (61%)

Number of prior lines of therapy, n (%)

  0

1 (2%)

  1

7 (17%)

  2

13 (32%)

  ≥3

20 (49%)

KRAS mutation, n (%)

  Exon 2

36 (88%)

  Exon 3

3 (7%)

  Exon 4

2 (5%)

  1. ECOG PS Eastern Cooperative Oncology Group performance status, KRAS Kirsten rat sarcoma viral oncogene homologue.