Fig. 6: Schematic representation of the impact of uprosertib treatment combined with OXPHOS or MCT inhibition in cancer cells exposed to lactic acidosis.
From: Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells
a Alteration of cellular fate in the presence or absence of lactic acid. b Schematic of the possible metabolic effects associated with altered response to treatment. Exogenous lactic acid decouples glycolysis from OXPHOS as lactate (black arrows) is preferentially utilised via the TCA cycle over glucose (green arrows). ETC electron transport chain. This figure was produced and adapted using Servier Medical Art licensed under the Creative Commons Attribution 3.0 Unported License (https://www.servier.com).
