Table 3 Cardiac risk factors.
Baseline characteristic | Cardiac events (%) | N | Univariate OR (95% CI) | Univariate P-value | Multivariate OR (95% CI) | Multivariate P-value |
|---|---|---|---|---|---|---|
Baseline LVEF | 363 (8.67) | 4189 | ||||
>64% | 102 (4.82) | 2118 | – | – | – | – |
55–64% | 225 (12.03) | 1871 | 2.70 (2.12–3.44) | <0.001 | 2.32 (1.61–3.35) | <0.001 |
<55% | 36 (18.00) | 200 | 4.34 (2.87–6.55) | <0.001 | 3.10 (1.54–6.25) | 0.002 |
Diabetes Mellitus | 363 (8.66) | 4190 | ||||
No | 330 (8.32) | 3967 | – | – | – | – |
Yes | 33 (14.80) | 223 | 1.91 (1.30 to 2.82) | <0.001 | 1.85 (1.25 to 2.75) | 0.002 |
Doxorubicin cumulative dose | 205 (10.90) | 1880 | ||||
<240 mg/m2 | 109 (9.62) | 1133 | – | – | – | – |
≥240 mg/m2 | 96 (12.85) | 747 | 1.39 (1.04–1.85) | 0.028 | 1.36 (1.01 to 1.82) | 0.039 |
Epirubicin cumulative dose | 142 (6.79) | 2092 | ||||
<480 mg/m2 | 107 (5.88) | 1819 | – | – | – | – |
≥480 mg/m2 | 35 (12.82) | 273 | 2.35 (1.57–3.53) | <0.001 | 2.33 (1.55–3.51) | <0.001 |
BMI CATEGORY | 363 (8.66) | 4190 | ||||
<25 kg/m2 | 146 (7.34) | 1988 | – | – | – | – |
25–30 kg/m2 | 125 (9.23) | 1354 | 1.28 (1.00–1.65) | 0.050 | 1.65 (1.11–2.46) | 0.014 |
>30 kg/m2 | 92 (10.85) | 848 | 1.54 (1.17–2.02) | 0.002 | 2.21 (1.40–3.49) | <0.001 |
