Fig. 5: IDH2 knockdown induced radiosensitisation in murine xenografts. | British Journal of Cancer

Fig. 5: IDH2 knockdown induced radiosensitisation in murine xenografts.

From: Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling

Fig. 5: IDH2 knockdown induced radiosensitisation in murine xenografts.

a HE staining and IHC images of IDH2 of murine xenografts. Nuclei were counterstained with haematoxylin. Scale bar = 20 μm. b Tumours in the sh-NC and sh-IDH2 groups were harvested on day 30, while tumours in the sh-NC + R and sh-IDH2 + R groups were harvested on day 45. c Tumour volume was recorded every 3 days and presented as mean ± SD (n = 5). P value was calculated by two-tailed unpaired t test. d Immunoblots of cleaved caspase-3. e HE and TUNEL staining of murine xenografts. Nuclei were counterstained with haematoxylin and DAPI, respectively. Scale bar = 20 μm.

Back to article page