Fig. 4: ROC curves for HCC-IHC classifier and decision curve analysis for HCC-IHC classifier-based nomogram.

ROC curves for HCC-IHC classifier and seven staging systems in the training, testing and validation cohorts (a). Nomogram was compared to other stage systems in terms of the 1-, 3-, and 5-year RFS in the entire cohort (b). The horizontal solid black line represents the assumptions that no patient will experience the event, and the solid grey line represents the assumption that all patients will relapse. On decision curve analysis, nomogram showed better net benefit compared with other stage systems across a range of threshold probabilities.