Fig. 3: Multiple proteins in the kynurenine pathway are dysregulated in RCC. | British Journal of Cancer

Fig. 3: Multiple proteins in the kynurenine pathway are dysregulated in RCC.

From: Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion

Fig. 3: Multiple proteins in the kynurenine pathway are dysregulated in RCC.The alternative text for this image may have been generated using AI.

Mass spectrometric relative concentrations (LFQ intensity) of proteins in the kynurenine pathway for paired normal kidney/tumour tissue samples (black and grey bars, respectively) for a ccRCC and b chromophobe RCC. Numbers along x-axis refer to assigned tissue sample number. Differences between groups by Wilcoxon matched-pairs sign rank test: Clear cell RCC: QPRT (p < 0.001), KMO (p < 0.001), HAAO (p = 0.01), and NAMPT (p < 0.01); Chromophobe RCC: QPRT (p < 0.016), KMO (p < 0.016), HAAO (p < 0.016), and NAMPT (p < 0.016).

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