Fig. 5: Alterations to the kynurenine pathway in RCC. | British Journal of Cancer

Fig. 5: Alterations to the kynurenine pathway in RCC.

From: Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion

Fig. 5: Alterations to the kynurenine pathway in RCC.The alternative text for this image may have been generated using AI.

The various enzymes and intermediates generated through this de novo synthesis of NAD+ from tryptophan are shown together with the salvage pathway route for generation of NAD+ from nicotinamide, catalysed by NAMPT. Enzymes for which we have strong evidence of downregulation in RCC tissues are marked with a solid grey arrow. Enzymes or substrates observed to be upregulated are marked with a hatched arrow. Enzymes with evidence to suggest they may be down regulated are marked by an open grey arrow.

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