Fig. 4: Example of the functional imaging and pathology from a patient with a lymph node metastasis.

a An image from the 3D-morphometric scan of the specimen. b The 3D-morphometric scan fused with the digitalised pathology. c The FDG-PET scan. d The DWI scan. e The DCE scan. The black contour illustrates the tumour defined by the pathologist, and the black circle represents the areas where the core biopsy was taken. f illustrates an example from the TMA block stained with p53. The black circle depicts the core biopsy shown above (a–e). In panel g, the core biopsy is magnified. h shows the same TMA stained for CAIX, and in panel i the core biopsy is magnified.