Table 1 Baseline characteristics stratified by cohort.
Cohort A | Cohort B | Cohort C | ||
|---|---|---|---|---|
Semi-quantitative IHC | Quantitative IHC | Flow cytometry | ||
n = 117 (%) | n = 34 (%) | n = 79 (%) | ||
Centre | Erasmus MC | 79 (68) | 34 (100) | 79 (100) |
UMCG | 38 (32) | 0 (0) | 0 (0) | |
Age at resection of CRLM (median [IQR]) | 67.0 [61.0, 73.0] | 64.5 [57.2, 72.0] | 67.0 [59.0, 75.0] | |
Gender | Female | 50 (43) | 11 (32) | 29 (37) |
Male | 67 (57) | 23 (68) | 50 (63) | |
Primary tumour location | Left sided | 48 (41) | 17 (50) | 40 (51) |
Right sided | 48 (41) | 11 (32) | 25 (32) | |
Rectal | 21 (18) | 5 (15) | 11 (14) | |
Missing | 0 (0) | 1 (3) | 3 (4) | |
Adjuvant CTx following CRC resection | No | 85 (73) | 31 (91) | 63 (80) |
Yes | 30 (26) | 3 (9) | 15 (19) | |
Missing | 2 (2) | 0 (0) | 1 (1) | |
Nodal status of primary CRC | N0 | 59 (50) | 18 (53) | 39 (49) |
N+ | 58 (50) | 14 (41) | 39 (49) | |
Missing | 0 (0) | 2 (6) | 1 (1) | |
Disease-free interval in monthsa (median [IQR]) | 15.0 [4.0, 25.0] | 7.0 [0.0, 17.5] | 8.0 [0.0, 18.5] | |
Preoperative CEA in µg/L (median [IQR]) | 16.1 [4.6, 50.5] | 6.0 [3.9, 17.0] | 13.0 [5.6, 29.1] | |
Number of CRLM (median [IQR]) | 1.0 [1.0, 2.0] | 2.0 [1.0, 2.0] | 1.0 [1.0, 2.0] | |
Diameter of largest CRLM in cm (median [IQR]) | 3.4 [2.5, 4.5] | 2.4 [1.5, 3.5] | 3.0 [2.0, 3.8] | |
Clinical Risk Score | Low risk (0–2) | 101 (86) | 22 (65) | 57 (72) |
High risk (3–5) | 16 (14) | 8 (24) | 17 (22) | |
Missing | 0 (0) | 4 (12) | 5 (6) | |
Histopathological growth pattern | dHGP | 32 (27) | 10 (29) | 12 (15) |
non-dHGP | 85 (73) | 24 (71) | 67 (85) | |
