Fig. 1: Females live longer than males in a metastatic model of CRC, and survival is correlated with increased CD8 T cells in the TME.
From: The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer
105 MC38 cells were delivered intraperitoneally to syngeneic male and female mice. a Females had increased survival, and b a higher percentage of CD8+ T cells in the TIL population, as assessed by FCA. c IHC staining with anti-CD8 confirmed greater infiltration of CD8 + cells in females. d Mice were divided by CD8+ infiltration, as assessed by FCA, into high (above mean) and low (below mean) groups. High infiltration correlated with survival (n = 5–10). *p < 0.050, **p < 0.010.
