Fig. 2: Kaplan-Meier survival by cycle 1–2 maximum grade neutropenia.
From: Early treatment-related neutropenia predicts response to palbociclib
a All patients. Grade 0: (reference); median PFS 6.0 weeks. Grade 1: HR 0.65 (0.40–1.07), p = 0.092; median PFS 8.1 weeks. Grade 2: HR 0.60 (0.40–0.90), p = 0.014; median PFS 15.6 weeks. Grade 3: HR 0.49 (0.33–0.74), p = 0.001; median PFS 19.4 weeks. Grade 4: HR 0.19 (0.06–0.62), p = 0.006; median PFS 60.0 weeks. Overall log-rank p = 0.002. b Breast patients. Grade 0: (reference); median PFS 5.0 weeks. Grade 1: HR 0.30 (0.05–1.56), p = 0.152; median PFS 13.9 weeks. Grade 2: HR 0.27 (0.10–0.75), p = 0.012; median PFS 16.3 weeks. Grade 3: HR 0.33 (0.12–0.87), p = 0.024; median PFS 19.4 weeks. Grade 4: HR 0.05 (0.01–0.52), p = 0.011; median PFS 25.4 weeks. Overall log-rank p = 0.028. c Non-breast patients. Grade 0: (reference); median PFS 6.0 weeks. Grade 1: HR 0.73 (0.43–1.23), p = 0.232; median PFS 8.0 weeks. Grade 2: HR 0.66 (0.41–1.06), p = 0.083; median PFS 15.6 weeks. Grade 3: HR 0.46 (0.28–0.75), p = 0.002; median PFS 18.0 weeks. Grade 4: HR 0.20 (0.02–1.17), p = 0.071; median PFS 60.0 weeks. Overall log-rank p = 0.013.
