Table 1 Total unadjusted mean resource-use and cost by allocation arm.

From: The ProtecT randomised trial cost-effectiveness analysis comparing active monitoring, surgery, or radiotherapy for prostate cancer

	Active monitoring (n = 513)^a		Radiotherapy (n = 516)^a		Radical prostatectomy (n = 527)^a
	Mean number of units^b	Mean cost (£) (SD)	Mean number of units^b	Mean cost (£) (SD)	Mean number of units^b	Mean cost (£) (SD)
Hospital outpatients visits
Procedure-driven appointments
Protocol radiotherapy	7.77	846 (1608)	28.37	3090 (1665)	3.69	402 (1190)
Non-protocol radiotherapy	1.01	133 (631)	0.37	49 (377)	1.86	245 (835)
CT scan	0.29	26 (53)	0.88	81 (56)	0.22	20 (52)
Radiotherapy preparation	0.27	169 (279)	0.80	503 (252)	0.19	122 (249)
TRUS	0.35	19 (33)	0.29	16 (30)	0.29	16 (30)
Trial without a catheter	0.17	24 (57)	0.09	13 (43)	0.53	73 (73)
Bone scan	0.28	56 (176)	0.11	23 (97)	0.13	26 (102)
MRI scan	0.20	27 (59)	0.13	17 (53)	0.11	15 (45)
TRUS-guided biopsy	0.16	35 (83)	0.07	15 (113)	0.04	9 (47)
Chemotherapy	0.04	58 (663)	0.09	145 (1570)	0.03	50 (844)
Other procedures	0.50	60 (250)	0.32	57 (346)	0.34	55 (569)
Speciality-driven appointments
Urology	8.99	868 (787)	9.56	913 (795)	11.64	1122 (810)
Oncology	1.08	156 (463)	2.76	400 (646)	1.31	190 (536)
Uro-oncology	0.62	80 (205)	1.07	137 (235)	0.80	102 (199)
Other specialities^c	16.56	912 (519)	4.79	374 (577)	3.98	260 (493)
Total outpatient cost		3469 (2754)		5832 (3106)		2707 (2748)
Hospital day case stays
Flexible cystoscopy	0.11	51 (165)	0.06	29 (119)	0.08	35 (142)
Colonoscopy	0.04	21 (126)	0.07	34 (185)	0.02	8 (63)
TWOC	0.04	16 (83)	0.01	2 (29)	0.05	19 (92)
Sigmoidoscopy	0.01	5 (46)	0.04	19 (100)	0.02	7 (81)
Rigid cystoscopy	0.03	27 (160)	0.01	10 (107)	0.04	33 (189)
TRUS-guided biopsy	0.05	25 (117)	0.01	5 (52)	0.01	4 (46)
Education	0.02	10 (70)	0.01	4 (52)	0.02	9 (75)
Chemotherapy	0.01	13 (285)	0.01	21 (390)	0.03	57 (936)
Urodynamics	0.01	2 (25)	0.01	2 (25)	0.02	6 (43)
Brachytherapy	0.01	10 (97)	0.01	6 (75)	0.01	6 (75)
Other day case reasons	0.14	99 (427)	0.12	81 (417)	0.16	119 (505)
Total day case cost		277 (689)		214 (715)		303 (1299)
Hospital inpatient stays
Prostatectomy	0.25	1332 (2380)	0.11	578 (1709)	0.77	4013 (2347)
Infection	0.02	31 (278)	0.02	42 (721)	0.04	76 (509)
TURP	0.05	142 (667)	0.02	44 (333)	0.00	21 (379)
Brachytherapy	0.03	61 (347)	0.02	32 (240)	0.02	31 (237)
Bladder neck procedure	0.01	18 (213)	0.01	30 (278)	0.02	44 (443)
Insertion of urinary sphincter	0.01	129 (1238)	0.01	70 (796)	0.02	206 (1464)
Pain	0.01	17 (243)	0.01	10 (115)	0.02	28 (323)
Urinary retention	0.01	17 (143)	0.01	7 (94)	0.01	14 (131)
Rigid cystoscopy	0.00	3 (60)	0.01	19 (158)	0.01	16 (168)
Blood transfusion	0.02	18 (255)	0.00	0 (0)	0.00	4 (90)
Other inpatient stays	0.15	434 (2298)	0.08	235 (1458)	0.18	403 (2316)
Total inpatient cost		2202 (3956)		1068 (2854)		4855 (4055)
GP practice visits
By healthcare professional
GP	0.81	36 (79)	0.93	41 (86)	1.09	48 (92)
GP nurse	0.91	13 (38)	0.66	10 (34)	0.69	10 (36)
Other	0.05	1 (5)	0.07	1 (9)	0.12	2 (16)
By reason
PSA test	27.41	435 (142)	20.91	332 (140)	20.80	330 (138)
Hormone delivery	1.97	44 (146)	4.24	94 (87)	0.85	19 (87)
Total GP practice cost		528 (243)		477 (205)		409 (231)
Medications
Cyproterone acetate days^d	0.23	1 (5)	0.37	1 (7)	0.16	0 (4)
Hormone injections	2.48	277 (770)	3.96	331 (515)	1.20	154 (606)
Total medication cost		277 (770)		332 (515)		154 (606)
Total cost		6754 (5597)		7923 (4717)		8428 (5636)

^aGiven the missing data assumptions (Supplementary Table 2), resource-use was obtained for 1556 (95%) of the 1653 men randomised into the ProtecT study.
^bUnits refer as appropriate to: number of outpatient appointments; number of day case visits; number of inpatient stays; number of GP practice visits; number of medications; number of days.
^cIncludes Accident and Emergency visits that did not lead to a procedure costed by the HRG.
^dAssuming a daily dose of 200 mg.

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Table 1 Total unadjusted mean resource-use and cost by allocation arm.

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