Table 3 Concordance of dEGFR39 for plasma EGFR mutations compared to ARMS.

From: Plasma-based early screening and monitoring of EGFR mutations in NSCLC patients by a 3-color digital PCR assay

Mutant type

Patient count

PPA

(95% CI)

NPA

(95% CI)

OPA

(95% CI)

TP

FN

TN

FP

L858R/L861Q

6

0

26

1

100

60.97–100%

96.29

81.72–99.34%

96.97

84.68–99.46%

S768I

7

1

25

0

85.71

52.91–97.76%

100

86.68–100%

96.97

84.68–99.46%

G719X

1

0

32

0

100

20.65–100%

100

89.28–100%

100

89.57–100%

19Del

0

0

33

0

NA

100

89.57–100%

100

89.57–100%

20ins

1

0

32

0

100

20.65–100%

100

89.28–100%

100

89.57–100%

T790M

3

0

28

2

100

43.85–100%

93.33

78.68–98.15%

93.94

80.39–98.32%

Overall

15

1

14

3

9375.00

71.67–98.89%

82.35

58.97–93.81%

87.88

72.67–95.18%

  1. TP true positive, FN false negative, TN true negative, FP false positive, PPA positive predict agreement, NPA negative predict agreement, OPA overall predict agreement, CI confidence interval.
Back to article page