Table 3 Odds ratios and confidence intervals for metabolites and breast cancer risk in the E3N cohort.

From: Investigation of circulating metabolites associated with breast cancer risk by untargeted metabolomics: a case–control study nested within the French E3N cohort

Plasma metabolite or metabolite groupa

1D NMR 1H chemical shifts (ppm)

Study group

Scaled mean intensity (SD) in controlsb

Scaled mean intensity (SD) in casesb

Odds ratio (95% CI) per SD increase in plasma concentrationc

Odds ratio (FDR-adjusted CI) per SD increasec

Raw P-value

False discovery rate P-value

N-acetyl glycoproteins (Acetylation of proteins)

2.04, 2.07

All women

99.6 (8.4)

100.4 (8.3)

1.17 (1.05–1.31)

–

0.004

0.162

  

Post-menopausal

99.4 (8.5)

99.78

1.09 (0.96–1.24)

–

0.168

0.844

  

Pre-menopausal

100.1 (8.1)

102.89

1.53 (1.19–1.96)

1.53 (1.11–2.11)

0.001

0.015

  

Pre-menopausal, adjusted ethanol

100.1 (8.1)

102.89

1.43 (1.09–1.89)

–

0.011

0.194

Ethanol (Alcohol)

1.17

All women

99.9 (33.6)

100.1 (31.1)

1.14 (1.02–1.27)

–

0.021

0.351

  

Post-menopausal

100.7 (37.9)

99.5 (30.1)

1.05 (0.93–1.20)

–

0.409

0.913

  

Pre-menopausal

97.4 (8.1)

102.1 (34.4)

1.44 (1.13–1.83)

1.44 (1.05–1.97)

0.004

0.03

Histidine (Amino acid)

3.16, 3.23,

All women

99.4 (18.4)

100.6 (18.3)

1.10 (0.98–1.23)

–

0.1

0.535

 

7.04, 7.73

Post-menopausal

99.6 (18.1)

99.5 (18.2)

0.97 (0.85–1.10)

–

0.615

0.973

  

Pre-menopausal

98.6 (19.4)

104.2 (18.2)

1.70 (1.29–2.23)

1.70 (1.19–2.41)

<0.001

0.006

  

Pre-menopausal, adjusted ethanol

98.6 (19.4)

104.2 (18.2)

1.58 (1.18–2.12)

–

0.002

0.08

Glycerol (Alcohol)

3.56, 3.65

All women

99.7 (13.7)

100.3 (13.8)

1.07 (0.96–1.19)

–

0.217

0.767

  

Post-menopausal

99.3 (14.3)

98.9 (13.2)

0.97 (0.86–1.10)

–

0.649

0.973

  

Pre-menopausal

101.3 (11.4)

105.2 (14.7)

1.55 (1.19–2.02)

1.55 (1.11, 2.18)

0.001

0.015

  

Pre-menopausal, adjusted ethanol

101.3 (11.4)

105.2 (14.7)

1.40 (1.04–1.89)

–

0.025

0.194

Ornithine (Amino acid)

1.82

All women

99.8 (11.3)

100.2 (11.2)

1.07 (0.96–1.19)

–

0.2

0.767

  

Post-menopausal

100.1 (11.6)

99.7 (11.4)

0.99 (0.87–1.12)

–

0.882

0.973

  

Pre-menopausal

99 (10.2)

101.9 (10.5)

1.43 (1.13–1.82)

1.43 (1.06–1.95)

0.003

0.03

  

Pre-menopausal, adjusted ethanol

99 (10.2)

101.9 (10.5)

1.30 (1.00–1.70)

–

0.052

0.194

Leucine (Amino acid)

1.70, 1.71, 3.72

All women

99.6 (9.5)

100.4 (10.3)

1.06 (0.96–1.18)

–

0.262

0.767

  

Post-menopausal

99.6 (9.7)

100 (10.6)

1.00 (0.89–1.12)

–

0.959

0.973

  

Pre-menopausal

99.6 (8.9)

101.7 (9.2)

1.37 (1.08–1.74)

1.37 (1.01–1.86)

0.009

0.046

  

Pre-menopausal, adjusted ethanol

99.6 (8.9)

101.7 (9.2)

1.28 (1.00–1.64)

–

0.051

0.194

Albumin (Protein)

2.97

All women

99.913

100.113

1.04 (0.93–1.17)

–

0.468

0.767

  

Post-menopausal

99.1 (13.2)

98.5 (12.7)

0.95 (0.83–1.08)

–

0.425

0.913

  

Pre-menopausal

102.3 (12.2)

105.7 (12.4)

1.39 (1.09–1.78)

1.39 (1.02–1.91)

0.008

0.046

  

Pre-menopausal, adjusted ethanol

102.3 (12.2)

105.7 (12.4)

1.30 (1.00–1.70)

–

0.054

0.194

Glutamine (Amino acid)

2.1, 2.13, 2.43, 2.46

All women

99.9 (12.6)

100.1 (12.7)

1.03 (0.92–1.15)

–

0.632

0.767

  

Post-menopausal

99.7 (12.5)

99.1 (12.6)

0.94 (0.82–1.06)

–

0.314

0.913

  

Pre-menopausal

100.5 (12.8)

103.7 (12.2)

1.33 (1.07–1.67)

1.33 (1.00–1.78)

0.012

0.049

  

Pre-menopausal, adjusted ethanol

100.5 (12.8)

103.7 (12.2)

1.29 (1.02–1.63)

–

0.035

0.194

Glutamate (Amino acid)

2.04, 2.12, 2.34, 3.75

All women

99.8 (10.9)

100.2 (10.8)

1.03 (0.93–1.15)

–

0.557

0.767

  

Post-menopausal

99.6 (10.9)

99.2 (10.8)

0.94 (0.83–1.07)

–

0.364

0.913

  

Pre-menopausal

100.8 (10.9)

103.3 (10.1)

1.34 (1.07–1.68)

1.34 (1.00–1.79)

0.01

0.049

  

Pre-menopausal, adjusted ethanol

100.8 (10.9)

103.3 (10.1)

1.30 (1.02–1.66)

–

0.032

0.194

Pyruvate (Organic acid)

2.36

All women

99.6 (13.6)

100.4 (14.6)

1.03 (0.92–1.15)

–

0.579

0.767

  

Post-menopausal

99.3 (13.4)

98.9 (13.4)

0.94 (0.82–1.07)

–

0.331

0.913

  

Pre-menopausal

100.7 (14.2)

105.4 (17.4)

1.42 (1.11–1.81)

1.42 (1.04–1.94)

0.005

0.036

  

Pre-menopausal, adjusted ethanol

100.7 (14.2)

105.4 (17.4)

1.33 (1.03–1.73)

–

0.028

0.194

  1. aOnly metabolites whose FDR-adjusted P-values fell beneath the significance threshold of 0.05 in one of the study groups are tabulated.
  2. bWhere a value of 100 is attributed to the mean intensity in all participants.
  3. cModels were adjusted for smoking status, diabetes status, BMI, waist to hip ratio, daily alcohol intake, duration of hormone treatment at blood collection, waiting time before plasma fractionation and biobank storage time.
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