Fig. 4: EGFR upregulates CXCL11 in a positive feedback loop in ATC. | British Journal of Cancer

Fig. 4: EGFR upregulates CXCL11 in a positive feedback loop in ATC.

From: The role of anlotinib-mediated EGFR blockade in a positive feedback loop of CXCL11-EGF-EGFR signalling in anaplastic thyroid cancer angiogenesis

Fig. 4

a The average expression score of phospho-EGFR in tumour was higher than that in matched peritumour from ATC tissue microarray. b, c The strong positive correlation between CXCL11 and phospho-EGFR was found in ATC tumour, but not in peritumour. d, e CXCL11 production and AKT-mTOR signalling were influenced by EGFR knockdown in CAL-62 and KHM-5M cells. f Supernatants from CAL-62/siEGFR or KHM-5M/siEGFR cells with CXCL11 restoration could partly reverse the reduction of tube formation, cell migration and proliferation of HUVEC. g Supernatants from EGFR overexpression cells with CXCL11 depletion could attenuate the EGFR-activated tube formation, cell migration and proliferation of HUVEC in CAL-62 and KHM-5M. All data are obtained from three independent experiments. *P < 0.05; **P < 0.01; ****P < 0.0001.

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