Fig. 2: Construction of Hypoxia Enrichment Score.
From: Radiomics and radiogenomics in gliomas: a contemporary update
a–c show a 2D Gd-T1w MRI slice with expert-annotated necrosis (outlined in green), enhancing tumour (yellow) and oedematous regions (brown) in three different GBM patients that exhibited low, medium, and high hypoxia enrichment score (HES) respectively. The corresponding inverse difference moment (Haralick) feature map has been overlaid on the manually annotated tumour regions, for HESlow (d), HESmedium (e), and HEShigh (f). g Unsupervised clustering of the RNAseq data from the 21 hypoxia associated genes clustered as high hypoxia (HEShigh—shown in navy blue, medium hypoxia (HESmedium—shown in teal) and low hypoxia (HESlow—shown in yellow). The x axis in the clustergram represents the 21 genes and y axis represents the patient population of 97 GBM cases. Figure from Beig et al.87; licensed under a Creative Commons Attribution (CC BY) license.
