Table 2 Univariable and multi-variable Cox regression analysis for DFS.

From: Body mass index and absolute lymphocyte count predict disease-free survival in Korean breast cancer patients

 

Univariable analysis

Multi-variable analysis

 

HR (95% CI)

P-value

HR (95% CI)

P-value

Age, yearsa

1.00 (0.99–1.02)

0.775

  

BMI, kg/m2

  18.5–23.0

Ref. b

 

Ref.

 

  <18.5

0.76 (0.24–2.45)

0.644

0.50 (0.12–2.06)

0.334

  ≥23.0

1.57 (1.09–2.26)

0.016

1.98 (1.34–2.92)

0.001

WBC count, ×103/uLa

0.99 (0.89–1.09)

0.764

  

ALC, ×103/uLa

0.52 (0.37–0.74)

<0.001

0.43 (0.29–0.65)

<0.001

ANC, ×103/uLa

1.06 (0.96–1.17)

0.270

  

NLR, ×103/uLa

1.09 (1.04–1.14)

0.001

1.01 (0.94–1.07)

0.881

Platelet count, ×103/uLa

1.00 (0.99–1.00)

0.785

  

Monocyte count, ×103/uLa

1.72 (0.38–7.80)

0.484

  

Histologic grade

  Low

Ref.

 

Ref.

 

  Intermediate

1.51 (0.89–2.55)

0.128

0.94 (0.54–1.65)

0.831

  High

2.03 (1.18–3.50)

0.011

0.85 (0.44–1.65)

0.625

Nuclear grade

  Low

Ref.

   

  Intermediate

1.29 (0.64–2.60)

0.486

  

  High

1.94 (0.96–3.91)

0.065

  

Oestrogen receptor

  Negative

Ref.

 

Ref.

 

  Positive

0.54 (0.38–0.78)

0.001

0.82 (0.46–1.49)

0.516

Progesterone receptor

  Negative

Ref.

 

Ref.

 

  Positive

0.54 (0.38–0.76)

<0.001

0.89 (0.50–1.56)

0.678

HER2

  Negative

Ref.

 

Ref.

 

  Positive

1.59 (1.10–2.31)

0.015

1.19 (0.80–1.79)

0.388

Ki-67 LI, %

  <14

Ref.

 

Ref.

 

  ≥14

2.40 (1.67–3.45)

<0.001

1.94 (1.22–3.07)

0.005

Tumour size, mm

  ≤20

Ref.

 

Ref.

 

  >20

2.12 (1.50–3.01)

<0.001

1.47 (1.00–2.18)

0.050

Positive lymph node, count

  0

Ref.

 

Ref.

 

  1–3

1.16 (0.77–1.76)

0.471

1.00 (0.65–1.55)

0.992

  ≥4

2.17 (1.27–3.73)

0.005

1.30 (0.72–2.34)

0.385

  1. ALC absolute lymphocyte count, ANC absolute neutrophil count, BMI body mass index, CI confidence interval, DFS disease-free survival, HER2 human epidermal growth factor receptor 2, HR hazard ratio, LI labelling index, NLR neutrophil-to-lymphocyte ratio, WBC white blood cell.
  2. aContinuous variable.
  3. bReference value.
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